Blog

The first 90 days,
explained.

Practical, evidence-based articles on starting an SSRI or SNRI — what to expect, how to track, and when to call your prescriber.

Latest articles

Side Effects

Common Antidepressant Side Effects, in Plain Language

Which side effects are common, which tend to ease by week three, and which warrant a sooner conversation — from TGA, FDA, NICE, RANZCP, and Royal College of Psychiatrists resources.

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Tracking

How to Tell If Your Antidepressant Is Working

The early signs are subtle and almost never look like "I feel amazing." Major guidelines describe the first meaningful response as appearing between weeks four and six — and knowing what to look for changes how you read the experience.

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Side Effects

Why Anxiety Can Get Worse When Starting an Antidepressant

NICE, RANZCP, and major prescribing resources all document this early bump. Here's why it happens, what it tends to feel like, how long it lasts, and what helps you get through it.

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Overview

The First 90 Days on an Antidepressant: Why This Window Matters Most

Cochrane reviews and population studies consistently identify the first 90 days as the highest-risk window for discontinuation. Here's why it's structurally hard, what's typical at each stage, and what the evidence says helps.

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Mood

Emotional Blunting on an Antidepressant: What the Research Says

A muted, distant quality to feeling affects a third to half of people on long-term antidepressants. Here's what the evidence says about why it happens, whether it eases, and what options exist.

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Sleep

Antidepressant Insomnia: When Does It Get Better?

Disturbed sleep is common in the first weeks on an antidepressant and improves for most people by week three or four. Here's what clinical guidance says about timing, and what actually helps.

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First Month

The First Month on an Antidepressant: A Week-by-Week Timeline

Clinical guidance describes the same arc every time: side effects first, the trough in week two, the body settling in week three, and the first mood shift in week four. Here's what that looks like.

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Week 1

What Actually Happens in the First Week on an Antidepressant

A research-informed guide to the first seven days — what clinical guidance says is typical, what the evidence shows about adherence, and what to flag to your prescriber.

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Tracking your first 90 days?

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