How to Ask Your Prescriber for a Dose Change

Asking for a dose change is a standard clinical conversation. NICE NG222, RANZCP, and Royal College of Psychiatrists guidance describe dose adjustments as routine parts of antidepressant treatment optimisation. You do not need to argue for the change — you just need to describe what you have been experiencing.

When a dose change conversation is appropriate

Partial response — some improvement but not enough. Side effects that are affecting daily life. Persistence of specific symptoms despite overall improvement. A defined timepoint like the six-week review where adjustments are standard. Return of symptoms after previously being stable. Life changes affecting treatment needs. All of these are routine reasons for dose review.

What to bring to the appointment

A written summary of the last few weeks: what has improved, what has not, what side effects are present. Specific examples rather than general descriptions. Your daily notes if you have kept them. A clear statement of what you would like to discuss: 'I think a dose change might be worth considering' is enough. The prescriber will assess and either agree, suggest a different approach, or explain why the current dose is right.

What the prescriber may consider

An increase to address partial response. A decrease to address side effects while maintaining most of the benefit. A switch to a different medication if the current dose range is not working. Augmentation with a second medication for specific persistent symptoms. Delaying the change to allow more time on the current dose. The right approach depends on your specific situation.

What to flag to your prescriber

Prescriber unwilling to consider adjustment without adequate explanation.
Any rushed decision without full discussion.
Uncertainty about whether the recommended change is right for you.
Sudden severe reaction to the new dose after any change.

Frequently asked questions

Can I ask my GP to increase my antidepressant?

Yes. Dose adjustments are routine. Bring specific examples of what has and has not improved.

What if my GP disagrees about changing the dose?

Ask the reasoning. Sometimes waiting longer is clinically appropriate; sometimes a second opinion helps.

How quickly can I change the dose?

Depends on the medication. Some are adjusted immediately; others require a more gradual approach. Your prescriber will advise.

Evidence and sources referenced

NICE Guideline NG222 — Depression in adults: treatment and management (United Kingdom).
Royal Australian and New Zealand College of Psychiatrists (RANZCP) — Clinical Practice Guidelines for Mood Disorders.
NPS MedicineWise — patient and prescriber resources on antidepressants (Australia).
Royal College of Psychiatrists — patient information on antidepressants.
TGA and FDA — product information for SSRI and SNRI classes.
Maudsley Prescribing Guidelines in Psychiatry.

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